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SMILES: COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccc(F)c(Cl)c3)ccc2s1

InChI Key: InChIKey=LSCZCXFQEGSDNF-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 365338   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM365338 (US10633373, Example 43 | US10669265, Example 43 | ...) Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccc(F)c(Cl)c3)ccc2s1 Show InChI InChI=1S/C22H15ClFN3O3S/c1-30-22(29)13-7-15(20(25)26-10-13)19-9-12-6-14(3-5-18(12)31-19)27-21(28)11-2-4-17(24)16(23)8-11/h2-10H,1H3,(H2,25,26)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	264	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...				J Med Chem 50: 3515-27 (2007) BindingDB Entry DOI: 10.7270/Q2DB8465
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM365338 (US10633373, Example 43 | US10669265, Example 43 | ...) Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccc(F)c(Cl)c3)ccc2s1 Show InChI InChI=1S/C22H15ClFN3O3S/c1-30-22(29)13-7-15(20(25)26-10-13)19-9-12-6-14(3-5-18(12)31-19)27-21(28)11-2-4-17(24)16(23)8-11/h2-10H,1H3,(H2,25,26)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...				J Med Chem 50: 3515-27 (2007) BindingDB Entry DOI: 10.7270/Q2DB8465
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM365338 (US10633373, Example 43 | US10669265, Example 43 | ...) Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccc(F)c(Cl)c3)ccc2s1 Show InChI InChI=1S/C22H15ClFN3O3S/c1-30-22(29)13-7-15(20(25)26-10-13)19-9-12-6-14(3-5-18(12)31-19)27-21(28)11-2-4-17(24)16(23)8-11/h2-10H,1H3,(H2,25,26)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...				US Patent US10669265 (2020)
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM365338 (US10633373, Example 43 | US10669265, Example 43 | ...) Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccc(F)c(Cl)c3)ccc2s1 Show InChI InChI=1S/C22H15ClFN3O3S/c1-30-22(29)13-7-15(20(25)26-10-13)19-9-12-6-14(3-5-18(12)31-19)27-21(28)11-2-4-17(24)16(23)8-11/h2-10H,1H3,(H2,25,26)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Allergan, Inc. US Patent					Assay Description PDGFRβ: Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu...				US Patent US10633373 (2020)
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM365338 (US10633373, Example 43 | US10669265, Example 43 | ...) Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccc(F)c(Cl)c3)ccc2s1 Show InChI InChI=1S/C22H15ClFN3O3S/c1-30-22(29)13-7-15(20(25)26-10-13)19-9-12-6-14(3-5-18(12)31-19)27-21(28)11-2-4-17(24)16(23)8-11/h2-10H,1H3,(H2,25,26)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	264	n/a	n/a	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...				US Patent US10669265 (2020)
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM365338 (US10633373, Example 43 | US10669265, Example 43 | ...) Show SMILES COC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)c3ccc(F)c(Cl)c3)ccc2s1 Show InChI InChI=1S/C22H15ClFN3O3S/c1-30-22(29)13-7-15(20(25)26-10-13)19-9-12-6-14(3-5-18(12)31-19)27-21(28)11-2-4-17(24)16(23)8-11/h2-10H,1H3,(H2,25,26)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	264	n/a	n/a	n/a	n/a	n/a	n/a
Allergan, Inc. US Patent					Assay Description VEGFR2: Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:...				US Patent US10633373 (2020)
					More data for this Ligand-Target Pair