BDBM36544 DFP-4AB::Diphenylfuropyrimidine-4-aminobutanol

SMILES: OCCCCNc1ncnc2oc(c(-c3ccccc3)c12)-c1ccccc1

InChI Key: InChIKey=MZZJDWBWZMUWDF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 36544   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase HCK (Homo sapiens (Human))	BDBM36544 (DFP-4AB | Diphenylfuropyrimidine-4-aminobutanol) Show SMILES OCCCCNc1ncnc2oc(c(-c3ccccc3)c12)-c1ccccc1 Show InChI InChI=1S/C22H21N3O2/c26-14-8-7-13-23-21-19-18(16-9-3-1-4-10-16)20(17-11-5-2-6-12-17)27-22(19)25-15-24-21/h1-6,9-12,15,26H,7-8,13-14H2,(H,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	25
University of Pittsburgh School of Medicine					Assay Description In vitro kinase activity of Nef-Hck complex and Hck alone using Z'-lyte kinase assay system and Tyr2 peptide substrate from Invitrogen.				ACS Chem Biol 4: 939-47 (2009) Article DOI: 10.1021/cb900195c BindingDB Entry DOI: 10.7270/Q2PG1Q32
					More data for this Ligand-Target Pair
Tryrosine-Protein Kinase (HCK) + Protein Nef (NEF) (Homo sapiens (Human)-Human immunodeficiency virus ...)	BDBM36544 (DFP-4AB | Diphenylfuropyrimidine-4-aminobutanol) Show SMILES OCCCCNc1ncnc2oc(c(-c3ccccc3)c12)-c1ccccc1 Show InChI InChI=1S/C22H21N3O2/c26-14-8-7-13-23-21-19-18(16-9-3-1-4-10-16)20(17-11-5-2-6-12-17)27-22(19)25-15-24-21/h1-6,9-12,15,26H,7-8,13-14H2,(H,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	25
University of Pittsburgh School of Medicine					Assay Description In vitro kinase activity of Nef-Hck complex and Hck alone using Z'-lyte kinase assay system and Tyr2 peptide substrate from Invitrogen.				ACS Chem Biol 4: 939-47 (2009) Article DOI: 10.1021/cb900195c BindingDB Entry DOI: 10.7270/Q2PG1Q32
					More data for this Ligand-Target Pair