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SMILES: CCS(=O)(=O)c1ccc(CNC(=O)c2nc3[C@H](C(C)C)N(Cc4ccc5OC(F)(F)Oc5c4)Cc3s2)nc1

InChI Key: InChIKey=OBPHFGQRSUJOHK-QFIPXVFZSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 365729   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM365729
PNG
(US9868748, I-L3)
Show SMILES CCS(=O)(=O)c1ccc(CNC(=O)c2nc3[C@H](C(C)C)N(Cc4ccc5OC(F)(F)Oc5c4)Cc3s2)nc1
Show InChI InChI=1S/C25H26F2N4O5S2/c1-4-38(33,34)17-7-6-16(28-11-17)10-29-23(32)24-30-21-20(37-24)13-31(22(21)14(2)3)12-15-5-8-18-19(9-15)36-25(26,27)35-18/h5-9,11,14,22H,4,10,12-13H2,1-3H3,(H,29,32)/t22-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Compounds of the present invention were tested for ability to bind to RORγ in a cell-free competition assay with commercially available radio-li...

J Med Chem 45: 1399-401 (2002)


BindingDB Entry DOI: 10.7270/Q2W95CHZ
More data for this
Ligand-Target Pair