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SMILES: Fc1cc(Cn2cccc(C(=O)NCc3noc(n3)-c3c[nH]c4ncccc34)c2=O)ccc1C(F)(F)F

InChI Key: InChIKey=JLHBAMYZQQKUQN-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 366218   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3-phosphoinositide-dependent protein kinase 1 [51-360]


(Homo sapiens (Human))		BDBM366218
PNG
(US9873693, Compound 141)
Show SMILES Fc1cc(Cn2cccc(C(=O)NCc3noc(n3)-c3c[nH]c4ncccc34)c2=O)ccc1C(F)(F)F
Show InChI InChI=1S/C24H16F4N6O3/c25-18-9-13(5-6-17(18)24(26,27)28)12-34-8-2-4-15(23(34)36)21(35)31-11-19-32-22(37-33-19)16-10-30-20-14(16)3-1-7-29-20/h1-10H,11-12H2,(H,29,30)(H,31,35)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Duquesne University



Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...

J Med Chem 51: 68-76 (2008)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair