null

SMILES: OCC1(CCN(CC1)c1cccn2nc(Nc3ccc(cc3)C(=O)N3CCC(C3)c3ccncc3)nc12)c1ccc(Cl)cc1

InChI Key: InChIKey=BJJAJPOAVFRREY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 366682   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM366682 (US9873709, Example 1-279 | [4-[[8-[4-(4- chlorophe...) Show SMILES OCC1(CCN(CC1)c1cccn2nc(Nc3ccc(cc3)C(=O)N3CCC(C3)c3ccncc3)nc12)c1ccc(Cl)cc1 Show InChI InChI=1S/C34H34ClN7O2/c35-28-7-5-27(6-8-28)34(23-43)14-20-40(21-15-34)30-2-1-18-42-31(30)38-33(39-42)37-29-9-3-25(4-10-29)32(44)41-19-13-26(22-41)24-11-16-36-17-12-24/h1-12,16-18,26,43H,13-15,19-23H2,(H,37,39)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM366682 (US9873709, Example 1-279 | [4-[[8-[4-(4- chlorophe...) Show SMILES OCC1(CCN(CC1)c1cccn2nc(Nc3ccc(cc3)C(=O)N3CCC(C3)c3ccncc3)nc12)c1ccc(Cl)cc1 Show InChI InChI=1S/C34H34ClN7O2/c35-28-7-5-27(6-8-28)34(23-43)14-20-40(21-15-34)30-2-1-18-42-31(30)38-33(39-42)37-29-9-3-25(4-10-29)32(44)41-19-13-26(22-41)24-11-16-36-17-12-24/h1-12,16-18,26,43H,13-15,19-23H2,(H,37,39)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.410	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair