null

SMILES: C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)N2CCC(CO)(CC2)c2ccc(Cl)cc2)cc1

InChI Key: InChIKey=ADVIMOZEXAPFEG-WMPKNSHKSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 366685   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM366685 (US9873709, Example 1-282 | [4-[[8-[4-(4- chlorophe...) Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)N2CCC(CO)(CC2)c2ccc(Cl)cc2)cc1 |r| Show InChI InChI=1S/C36H44ClN7O3/c1-25-22-43(23-26(2)47-25)31-13-18-42(19-14-31)34(46)27-5-11-30(12-6-27)38-35-39-33-32(4-3-17-44(33)40-35)41-20-15-36(24-45,16-21-41)28-7-9-29(37)10-8-28/h3-12,17,25-26,31,45H,13-16,18-24H2,1-2H3,(H,38,40)/t25-,26+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM366685 (US9873709, Example 1-282 | [4-[[8-[4-(4- chlorophe...) Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)N2CCC(CO)(CC2)c2ccc(Cl)cc2)cc1 |r| Show InChI InChI=1S/C36H44ClN7O3/c1-25-22-43(23-26(2)47-25)31-13-18-42(19-14-31)34(46)27-5-11-30(12-6-27)38-35-39-33-32(4-3-17-44(33)40-35)41-20-15-36(24-45,16-21-41)28-7-9-29(37)10-8-28/h3-12,17,25-26,31,45H,13-16,18-24H2,1-2H3,(H,38,40)/t25-,26+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.370	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair