BDBM366713 US9873709, Example 2-7::cyanomethyl 4-[2-[4- [methyl-(1-methyl-4- piperidyl)carbamoyl] anilino]- [1,2,4]triazolo[1,5- a]pyridin-8-yl]-3,6- dihydro-2H-pyridine- 1-carboxylate

SMILES: CN(C1CCN(C)CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)C(=O)OCC#N)cc1

InChI Key: InChIKey=BSQPVOSBHVREQY-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 366713   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM366713 (US9873709, Example 2-7 | cyanomethyl 4-[2-[4- [met...) Show SMILES CN(C1CCN(C)CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)C(=O)OCC#N)cc1 |t:28| Show InChI InChI=1S/C28H32N8O3/c1-33-15-11-23(12-16-33)34(2)26(37)21-5-7-22(8-6-21)30-27-31-25-24(4-3-14-36(25)32-27)20-9-17-35(18-10-20)28(38)39-19-13-29/h3-9,14,23H,10-12,15-19H2,1-2H3,(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM366713 (US9873709, Example 2-7 | cyanomethyl 4-[2-[4- [met...) Show SMILES CN(C1CCN(C)CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)C(=O)OCC#N)cc1 |t:28| Show InChI InChI=1S/C28H32N8O3/c1-33-15-11-23(12-16-33)34(2)26(37)21-5-7-22(8-6-21)30-27-31-25-24(4-3-14-36(25)32-27)20-9-17-35(18-10-20)28(38)39-19-13-29/h3-9,14,23H,10-12,15-19H2,1-2H3,(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair