null

SMILES: CN(C1CCN(C)CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)C(=O)CC(F)(F)F)cc1

InChI Key: InChIKey=FSBWGNSNLWKAHE-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 366869   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM366869 (N-methyl-N-(1- methyl-4-piperidyl)-4- [[8-[1-(3,3,...) Show SMILES CN(C1CCN(C)CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)C(=O)CC(F)(F)F)cc1 |t:28| Show InChI InChI=1S/C28H32F3N7O2/c1-35-14-11-22(12-15-35)36(2)26(40)20-5-7-21(8-6-20)32-27-33-25-23(4-3-13-38(25)34-27)19-9-16-37(17-10-19)24(39)18-28(29,30)31/h3-9,13,22H,10-12,14-18H2,1-2H3,(H,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM366869 (N-methyl-N-(1- methyl-4-piperidyl)-4- [[8-[1-(3,3,...) Show SMILES CN(C1CCN(C)CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)C(=O)CC(F)(F)F)cc1 |t:28| Show InChI InChI=1S/C28H32F3N7O2/c1-35-14-11-22(12-15-35)36(2)26(40)20-5-7-21(8-6-20)32-27-33-25-23(4-3-13-38(25)34-27)19-9-16-37(17-10-19)24(39)18-28(29,30)31/h3-9,13,22H,10-12,14-18H2,1-2H3,(H,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair