BDBM366918 N-methyl-N-[2-(3- pyridyl)ethyl]-4-[[8- [1-(4,4,4- trifluorobutanoyl)-3,6- dihydro-2H-pyridin-4- yl]-[1,2,4]triazolo[1,5- a]pyridin-2- yl]amino]benzamide::US9873709, Example 2-212
SMILES: CN(CCc1cccnc1)C(=O)c1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)C(=O)CCC(F)(F)F)cc1
InChI Key: InChIKey=PYPRATHDAHADLH-UHFFFAOYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM366918 (N-methyl-N-[2-(3- pyridyl)ethyl]-4-[[8- [1-(4,4,4-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University | Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A... | J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM366918 (N-methyl-N-[2-(3- pyridyl)ethyl]-4-[[8- [1-(4,4,4-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.910 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University | Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A... | J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F | |||||||||||
More data for this Ligand-Target Pair |