BDBM366984 4,4,4-trifluoro-1-[4-[2- [4-[2-(3- pyridyl)piperidine-1- carbonyl]anilino]- [1,2,4]triazolo[1,5- a]pyridin-8-yl]-3,6- dihydro-2H-pyridin-1- yl]butan-1-one::US9873709, Example 2-280

SMILES: FC(F)(F)CCC(=O)N1CCC(=CC1)c1cccn2nc(Nc3ccc(cc3)C(=O)N3CCCCC3c3cccnc3)nc12

InChI Key: InChIKey=YTMFSMOKEUZXRX-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 366984   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM366984 (4,4,4-trifluoro-1-[4-[2- [4-[2-(3- pyridyl)piperid...) Show SMILES FC(F)(F)CCC(=O)N1CCC(=CC1)c1cccn2nc(Nc3ccc(cc3)C(=O)N3CCCCC3c3cccnc3)nc12 |c:11| Show InChI InChI=1S/C32H32F3N7O2/c33-32(34,35)15-12-28(43)40-19-13-22(14-20-40)26-6-4-18-42-29(26)38-31(39-42)37-25-10-8-23(9-11-25)30(44)41-17-2-1-7-27(41)24-5-3-16-36-21-24/h3-6,8-11,13,16,18,21,27H,1-2,7,12,14-15,17,19-20H2,(H,37,39)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM366984 (4,4,4-trifluoro-1-[4-[2- [4-[2-(3- pyridyl)piperid...) Show SMILES FC(F)(F)CCC(=O)N1CCC(=CC1)c1cccn2nc(Nc3ccc(cc3)C(=O)N3CCCCC3c3cccnc3)nc12 |c:11| Show InChI InChI=1S/C32H32F3N7O2/c33-32(34,35)15-12-28(43)40-19-13-22(14-20-40)26-6-4-18-42-29(26)38-31(39-42)37-25-10-8-23(9-11-25)30(44)41-17-2-1-7-27(41)24-5-3-16-36-21-24/h3-6,8-11,13,16,18,21,27H,1-2,7,12,14-15,17,19-20H2,(H,37,39)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.670	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair