null

SMILES: FC(F)(F)CCC(=O)N1CCC(=CC1)c1cccn2nc(Nc3ccc(cc3)C(=O)N3CCN(CC3)c3cccnc3)nc12

InChI Key: InChIKey=BAPVVISHQBYXRY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367096   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM367096 (4,4,4-trifluoro-1-[4-[2- [4-[4-(3- pyridyl)piperaz...) Show SMILES FC(F)(F)CCC(=O)N1CCC(=CC1)c1cccn2nc(Nc3ccc(cc3)C(=O)N3CCN(CC3)c3cccnc3)nc12 |c:11| Show InChI InChI=1S/C31H31F3N8O2/c32-31(33,34)12-9-27(43)40-15-10-22(11-16-40)26-4-2-14-42-28(26)37-30(38-42)36-24-7-5-23(6-8-24)29(44)41-19-17-39(18-20-41)25-3-1-13-35-21-25/h1-8,10,13-14,21H,9,11-12,15-20H2,(H,36,38)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM367096 (4,4,4-trifluoro-1-[4-[2- [4-[4-(3- pyridyl)piperaz...) Show SMILES FC(F)(F)CCC(=O)N1CCC(=CC1)c1cccn2nc(Nc3ccc(cc3)C(=O)N3CCN(CC3)c3cccnc3)nc12 |c:11| Show InChI InChI=1S/C31H31F3N8O2/c32-31(33,34)12-9-27(43)40-15-10-22(11-16-40)26-4-2-14-42-28(26)37-30(38-42)36-24-7-5-23(6-8-24)29(44)41-19-17-39(18-20-41)25-3-1-13-35-21-25/h1-8,10,13-14,21H,9,11-12,15-20H2,(H,36,38)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.650	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair