BDBM367247 US10226464, Compound 16

SMILES: Oc1ccc2cc3c(nc(=S)[nH]c3=O)oc2c1

InChI Key: InChIKey=AJLIGPHIWXUDFJ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367247   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear factor NF-kappa-B (NF-kB) (Homo sapiens (Human))	BDBM367247 (US10226464, Compound 16) Show SMILES Oc1ccc2cc3c(nc(=S)[nH]c3=O)oc2c1 Show InChI InChI=1S/C11H6N2O3S/c14-6-2-1-5-3-7-9(15)12-11(17)13-10(7)16-8(5)4-6/h1-4,14H,(H,12,15,17)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description NFκB/Jurkat/GFP transcriptional reporter cell line was obtained from SBI System Biosciences. NF-κB/Jurkat/GFP™ Reporter cells (5×105 cells)...				Bioorg Med Chem Lett 17: 5384-9 (2007) BindingDB Entry DOI: 10.7270/Q2028TVG
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB) (Homo sapiens (Human))	BDBM367247 (US10226464, Compound 16) Show SMILES Oc1ccc2cc3c(nc(=S)[nH]c3=O)oc2c1 Show InChI InChI=1S/C11H6N2O3S/c14-6-2-1-5-3-7-9(15)12-11(17)13-10(7)16-8(5)4-6/h1-4,14H,(H,12,15,17)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description DNA binding reaction (20 μL) was carried out in 1×DNA Binding Buffer (10 mM Tris, 40 mM NaCl, 1 mM EDTA, 4% glycerol) with 10 nM c-Rel protein a...				Bioorg Med Chem Lett 17: 5384-9 (2007) BindingDB Entry DOI: 10.7270/Q2028TVG
					More data for this Ligand-Target Pair