BDBM367294 US10226464, Compound 61
SMILES: COCCOCCOc1ccc2cc3c(nc(=O)[nH]c3=O)oc2c1
InChI Key: InChIKey=PYFBJPADTZBYMO-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nuclear factor NF-kappa-B (NF-kB) (Homo sapiens (Human)) | BDBM367294 (US10226464, Compound 61) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen | Assay Description NFκB/Jurkat/GFP transcriptional reporter cell line was obtained from SBI System Biosciences. NF-κB/Jurkat/GFP™ Reporter cells (5×105 cells)... | Bioorg Med Chem Lett 17: 5384-9 (2007) BindingDB Entry DOI: 10.7270/Q2028TVG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear factor NF-kappa-B (NF-kB) (Homo sapiens (Human)) | BDBM367294 (US10226464, Compound 61) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen | Assay Description DNA binding reaction (20 μL) was carried out in 1×DNA Binding Buffer (10 mM Tris, 40 mM NaCl, 1 mM EDTA, 4% glycerol) with 10 nM c-Rel protein a... | Bioorg Med Chem Lett 17: 5384-9 (2007) BindingDB Entry DOI: 10.7270/Q2028TVG | |||||||||||
More data for this Ligand-Target Pair |