BDBM367626 N-((1R,2R)-3-(azetidin-1-yl)-1-(4- cyclopropoxyphenyl)-1-hydroxypropan- 2-yl)-7-(5-chlorothiophen-2-yl)-1H- benzo[d][1,2]oxazine-4-carboxamide::US10227312, Example 11::US10759769, Example 11

SMILES: O[C@@H]([C@@H](CN1CCC1)NC(=O)C1=NOCc2cc(ccc12)-c1ccc(Cl)s1)c1ccc(OC2CC2)cc1

InChI Key: InChIKey=VJZKNKKIMVYKCX-YIXXDRMTSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367626   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ceramide glucosyltransferase (Homo sapiens (Human))	BDBM367626 (N-((1R,2R)-3-(azetidin-1-yl)-1-(4- cyclopropoxyphe...) Show SMILES O[C@@H]([C@@H](CN1CCC1)NC(=O)C1=NOCc2cc(ccc12)-c1ccc(Cl)s1)c1ccc(OC2CC2)cc1 |r,t:12| Show InChI InChI=1S/C28H28ClN3O4S/c29-25-11-10-24(37-25)18-4-9-22-19(14-18)16-35-31-26(22)28(34)30-23(15-32-12-1-13-32)27(33)17-2-5-20(6-3-17)36-21-7-8-21/h2-6,9-11,14,21,23,27,33H,1,7-8,12-13,15-16H2,(H,30,34)/t23-,27-/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Protein concentration was determined using BCA assay kit. Sixty micrograms of MDCK cell lysate was incubated with various concentrations of a compoun...				US Patent US10759769 (2020)
					More data for this Ligand-Target Pair
Ceramide glucosyltransferase (Homo sapiens (Human))	BDBM367626 (N-((1R,2R)-3-(azetidin-1-yl)-1-(4- cyclopropoxyphe...) Show SMILES O[C@@H]([C@@H](CN1CCC1)NC(=O)C1=NOCc2cc(ccc12)-c1ccc(Cl)s1)c1ccc(OC2CC2)cc1 |r,t:12| Show InChI InChI=1S/C28H28ClN3O4S/c29-25-11-10-24(37-25)18-4-9-22-19(14-18)16-35-31-26(22)28(34)30-23(15-32-12-1-13-32)27(33)17-2-5-20(6-3-17)36-21-7-8-21/h2-6,9-11,14,21,23,27,33H,1,7-8,12-13,15-16H2,(H,30,34)/t23-,27-/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description This assay was modified based on the study by Larsen et al. (J. Lipid Res. 2011, 53, 282). Madin-Darby canine kidney (MDCK) cell lysate was prepared ...				J Med Chem 51: 1319-23 (2008) BindingDB Entry DOI: 10.7270/Q2G44SK0
					More data for this Ligand-Target Pair