BDBM367656 N-((1R,2R)-1-(3-chloro-4- cyclopropoxyphenyl)-1-hydroxy-3- (pyrrolidin-1-yl)propan-2-yl)-6-(4- fluorophenyl)isochroman-1- carboxamide::US10227312, Example 42::US10759769, Example 42

SMILES: O[C@@H]([C@@H](CN1CCCC1)NC(=O)C1OCCc2cc(ccc12)-c1ccc(F)cc1)c1ccc(OC2CC2)c(Cl)c1

InChI Key: InChIKey=FONUWZNCWBJXAQ-JXOLXVKMSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367656   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ceramide glucosyltransferase (Homo sapiens (Human))	BDBM367656 (N-((1R,2R)-1-(3-chloro-4- cyclopropoxyphenyl)-1-hy...) Show SMILES O[C@@H]([C@@H](CN1CCCC1)NC(=O)C1OCCc2cc(ccc12)-c1ccc(F)cc1)c1ccc(OC2CC2)c(Cl)c1 |r| Show InChI InChI=1S/C32H34ClFN2O4/c33-27-18-23(6-12-29(27)40-25-9-10-25)30(37)28(19-36-14-1-2-15-36)35-32(38)31-26-11-5-21(17-22(26)13-16-39-31)20-3-7-24(34)8-4-20/h3-8,11-12,17-18,25,28,30-31,37H,1-2,9-10,13-16,19H2,(H,35,38)/t28-,30-,31?/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Protein concentration was determined using BCA assay kit. Sixty micrograms of MDCK cell lysate was incubated with various concentrations of a compoun...				US Patent US10759769 (2020)
					More data for this Ligand-Target Pair
Ceramide glucosyltransferase (Homo sapiens (Human))	BDBM367656 (N-((1R,2R)-1-(3-chloro-4- cyclopropoxyphenyl)-1-hy...) Show SMILES O[C@@H]([C@@H](CN1CCCC1)NC(=O)C1OCCc2cc(ccc12)-c1ccc(F)cc1)c1ccc(OC2CC2)c(Cl)c1 |r| Show InChI InChI=1S/C32H34ClFN2O4/c33-27-18-23(6-12-29(27)40-25-9-10-25)30(37)28(19-36-14-1-2-15-36)35-32(38)31-26-11-5-21(17-22(26)13-16-39-31)20-3-7-24(34)8-4-20/h3-8,11-12,17-18,25,28,30-31,37H,1-2,9-10,13-16,19H2,(H,35,38)/t28-,30-,31?/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description This assay was modified based on the study by Larsen et al. (J. Lipid Res. 2011, 53, 282). Madin-Darby canine kidney (MDCK) cell lysate was prepared ...				J Med Chem 51: 1319-23 (2008) BindingDB Entry DOI: 10.7270/Q2G44SK0
					More data for this Ligand-Target Pair