BDBM367993 3-(2-aminobenzo[d]thiazol-4- yl)-6-((1s,3s)-3- aminocyclobutylsulfonyl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 180

SMILES: N[C@H]1C[C@H](C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O

InChI Key:

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 367993   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metallo-beta-lactamase type 2 (Serratia marcescens)	BDBM367993 (3-(2-aminobenzo[d]thiazol-4- yl)-6-((1s,3s)-3- ami...) Show SMILES N[C@H]1C[C@H](C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O |r,wU:3.5,1.0,(5.93,-4.48,;5.16,-3.15,;3.68,-2.75,;4.08,-1.26,;5.56,-1.66,;3.31,.07,;4.85,.07,;4.39,1.16,;1.77,.07,;1,-1.26,;-.54,-1.26,;-1.31,.07,;-2.85,.07,;-3.62,1.4,;-5.16,1.4,;-5.93,.07,;-5.16,-1.26,;-5.64,-2.73,;-4.39,-3.63,;-4.39,-5.17,;-3.15,-2.73,;-3.62,-1.26,;-.54,1.4,;-1.31,2.74,;-2.85,2.9,;-3.17,4.4,;-1.83,5.17,;-.69,4.14,;1.02,1.45,;1.79,2.78,;3.13,2.01,;2.56,4.12,;.46,3.55,)| Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...				J Med Chem 51: 1231-41 (2008) BindingDB Entry DOI: 10.7270/Q2Z60RCD
					More data for this Ligand-Target Pair
VIM-1 (Pseudomonas aeruginosa)	BDBM367993 (3-(2-aminobenzo[d]thiazol-4- yl)-6-((1s,3s)-3- ami...) Show SMILES N[C@H]1C[C@H](C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O |r,wU:3.5,1.0,(5.93,-4.48,;5.16,-3.15,;3.68,-2.75,;4.08,-1.26,;5.56,-1.66,;3.31,.07,;4.85,.07,;4.39,1.16,;1.77,.07,;1,-1.26,;-.54,-1.26,;-1.31,.07,;-2.85,.07,;-3.62,1.4,;-5.16,1.4,;-5.93,.07,;-5.16,-1.26,;-5.64,-2.73,;-4.39,-3.63,;-4.39,-5.17,;-3.15,-2.73,;-3.62,-1.26,;-.54,1.4,;-1.31,2.74,;-2.85,2.9,;-3.17,4.4,;-1.83,5.17,;-.69,4.14,;1.02,1.45,;1.79,2.78,;3.13,2.01,;2.56,4.12,;.46,3.55,)| Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.196	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...				J Med Chem 51: 1231-41 (2008) BindingDB Entry DOI: 10.7270/Q2Z60RCD
					More data for this Ligand-Target Pair
Beta-lactamase NDM-1 (Klebsiella pneumoniae)	BDBM367993 (3-(2-aminobenzo[d]thiazol-4- yl)-6-((1s,3s)-3- ami...) Show SMILES N[C@H]1C[C@H](C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O |r,wU:3.5,1.0,(5.93,-4.48,;5.16,-3.15,;3.68,-2.75,;4.08,-1.26,;5.56,-1.66,;3.31,.07,;4.85,.07,;4.39,1.16,;1.77,.07,;1,-1.26,;-.54,-1.26,;-1.31,.07,;-2.85,.07,;-3.62,1.4,;-5.16,1.4,;-5.93,.07,;-5.16,-1.26,;-5.64,-2.73,;-4.39,-3.63,;-4.39,-5.17,;-3.15,-2.73,;-3.62,-1.26,;-.54,1.4,;-1.31,2.74,;-2.85,2.9,;-3.17,4.4,;-1.83,5.17,;-.69,4.14,;1.02,1.45,;1.79,2.78,;3.13,2.01,;2.56,4.12,;.46,3.55,)| Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0830	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...				J Med Chem 51: 1231-41 (2008) BindingDB Entry DOI: 10.7270/Q2Z60RCD
					More data for this Ligand-Target Pair