null

SMILES: CNC1CCN(C1)c1cc(ccc1Nc1ccc(c(F)c1)S(=O)(=O)Nc1cscn1)C(F)(F)F

InChI Key: InChIKey=YZHSBAJGLZIGBN-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 368255   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM368255 (US10227338, Example 37) Show SMILES CNC1CCN(C1)c1cc(ccc1Nc1ccc(c(F)c1)S(=O)(=O)Nc1cscn1)C(F)(F)F Show InChI InChI=1S/C21H21F4N5O2S2/c1-26-15-6-7-30(10-15)18-8-13(21(23,24)25)2-4-17(18)28-14-3-5-19(16(22)9-14)34(31,32)29-20-11-33-12-27-20/h2-5,8-9,11-12,15,26,28-29H,6-7,10H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca					Assay Description In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...				J Med Chem 51: 1755-1763 (2008) BindingDB Entry DOI: 10.7270/Q2F47RFM
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM368255 (US10227338, Example 37) Show SMILES CNC1CCN(C1)c1cc(ccc1Nc1ccc(c(F)c1)S(=O)(=O)Nc1cscn1)C(F)(F)F Show InChI InChI=1S/C21H21F4N5O2S2/c1-26-15-6-7-30(10-15)18-8-13(21(23,24)25)2-4-17(18)28-14-3-5-19(16(22)9-14)34(31,32)29-20-11-33-12-27-20/h2-5,8-9,11-12,15,26,28-29H,6-7,10H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca					Assay Description In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...				J Med Chem 51: 1755-1763 (2008) BindingDB Entry DOI: 10.7270/Q2F47RFM
					More data for this Ligand-Target Pair