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SMILES: CN[C@H]1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1

InChI Key: InChIKey=HLVQEVJPDKUISY-ZDUSSCGKSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 368287   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM368287
PNG
(US10227338, Example 70)
Show SMILES CN[C@H]1CCN(C1)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1 |r|
Show InChI InChI=1S/C20H20ClF2N5O2S2/c1-24-13-4-5-28(9-13)18-6-12(22)2-3-16(18)26-17-8-15(23)19(7-14(17)21)32(29,30)27-20-10-31-11-25-20/h2-3,6-8,10-11,13,24,26-27H,4-5,9H2,1H3/t13-/m0/s1
PDB

KEGG

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PC cid
PC sid
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US Patent
n/an/a 50n/an/an/an/an/an/a



AstraZeneca



Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...

J Med Chem 51: 1755-1763 (2008)


BindingDB Entry DOI: 10.7270/Q2F47RFM
More data for this
Ligand-Target Pair