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SMILES: CNCCN(C)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccc(F)cn1)C(F)(F)F

InChI Key: InChIKey=AMIIVABFULXNKH-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 368322   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM368322
PNG
(US10227338, Example 109)
Show SMILES CNCCN(C)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccc(F)cn1)C(F)(F)F
Show InChI InChI=1S/C22H21ClF5N5O2S/c1-29-7-8-33(2)19-9-13(22(26,27)28)3-5-17(19)31-18-11-16(25)20(10-15(18)23)36(34,35)32-21-6-4-14(24)12-30-21/h3-6,9-12,29,31H,7-8H2,1-2H3,(H,30,32)
PDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



AstraZeneca



Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...

J Med Chem 51: 1755-1763 (2008)


BindingDB Entry DOI: 10.7270/Q2F47RFM
More data for this
Ligand-Target Pair