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SMILES: CNCCN(C)c1cc(OC)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1

InChI Key: InChIKey=CXHZIIZCSZQZCE-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 368332   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM368332
PNG
(US10227338, Example 119)
Show SMILES CNCCN(C)c1cc(OC)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H23ClFN5O3S2/c1-23-6-8-27(2)18-10-13(30-3)4-5-16(18)25-17-12-15(22)19(11-14(17)21)32(28,29)26-20-24-7-9-31-20/h4-5,7,9-12,23,25H,6,8H2,1-3H3,(H,24,26)
PDB

KEGG

UniProtKB/SwissProt

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PC cid
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US Patent
n/an/a 20n/an/an/an/an/an/a



AstraZeneca



Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...

J Med Chem 51: 1755-1763 (2008)


BindingDB Entry DOI: 10.7270/Q2F47RFM
More data for this
Ligand-Target Pair