BDBM370114 8-[(1R,3R)-3-hydroxycyclohexyl]-2-{[1-(methylsulfonyl)piperidin-4-yl]-amino}pyrido[2,3-d]pyrimidin-7(8H)-one::US10233188, Example 3::US10800783, Example 3

SMILES: CS(=O)(=O)N1CCC(CC1)Nc1ncc2ccc(=O)n([C@@H]3CCC[C@@H](O)C3)c2n1

InChI Key: InChIKey=VXSBVQGQHGROBA-HZPDHXFCSA-N

Data: 6 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 370114   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM370114 (8-[(1R,3R)-3-hydroxycyclohexyl]-2-{[1-(methylsulfo...) Show SMILES CS(=O)(=O)N1CCC(CC1)Nc1ncc2ccc(=O)n([C@@H]3CCC[C@@H](O)C3)c2n1 |r| Show InChI InChI=1S/C19H27N5O4S/c1-29(27,28)23-9-7-14(8-10-23)21-19-20-12-13-5-6-17(26)24(18(13)22-19)15-3-2-4-16(25)11-15/h5-6,12,14-16,25H,2-4,7-11H2,1H3,(H,20,21,22)/t15-,16-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CNRS					Assay Description The purpose of the CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a flu...				J Med Chem 45: 1477-86 (2002) BindingDB Entry DOI: 10.7270/Q2FX7CSG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM370114 (8-[(1R,3R)-3-hydroxycyclohexyl]-2-{[1-(methylsulfo...) Show SMILES CS(=O)(=O)N1CCC(CC1)Nc1ncc2ccc(=O)n([C@@H]3CCC[C@@H](O)C3)c2n1 |r| Show InChI InChI=1S/C19H27N5O4S/c1-29(27,28)23-9-7-14(8-10-23)21-19-20-12-13-5-6-17(26)24(18(13)22-19)15-3-2-4-16(25)11-15/h5-6,12,14-16,25H,2-4,7-11H2,1H3,(H,20,21,22)/t15-,16-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The purpose of the CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a flu...				US Patent US10800783 (2020)
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 (Homo sapiens (Human)-Mus musculus (mouse))	BDBM370114 (8-[(1R,3R)-3-hydroxycyclohexyl]-2-{[1-(methylsulfo...) Show SMILES CS(=O)(=O)N1CCC(CC1)Nc1ncc2ccc(=O)n([C@@H]3CCC[C@@H](O)C3)c2n1 |r| Show InChI InChI=1S/C19H27N5O4S/c1-29(27,28)23-9-7-14(8-10-23)21-19-20-12-13-5-6-17(26)24(18(13)22-19)15-3-2-4-16(25)11-15/h5-6,12,14-16,25H,2-4,7-11H2,1H3,(H,20,21,22)/t15-,16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...				US Patent US10800783 (2020)
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 (Homo sapiens (Human)-Mus musculus (mouse))	BDBM370114 (8-[(1R,3R)-3-hydroxycyclohexyl]-2-{[1-(methylsulfo...) Show SMILES CS(=O)(=O)N1CCC(CC1)Nc1ncc2ccc(=O)n([C@@H]3CCC[C@@H](O)C3)c2n1 |r| Show InChI InChI=1S/C19H27N5O4S/c1-29(27,28)23-9-7-14(8-10-23)21-19-20-12-13-5-6-17(26)24(18(13)22-19)15-3-2-4-16(25)11-15/h5-6,12,14-16,25H,2-4,7-11H2,1H3,(H,20,21,22)/t15-,16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CNRS					Assay Description The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...				J Med Chem 45: 1477-86 (2002) BindingDB Entry DOI: 10.7270/Q2FX7CSG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 (Homo sapiens (Human))	BDBM370114 (8-[(1R,3R)-3-hydroxycyclohexyl]-2-{[1-(methylsulfo...) Show SMILES CS(=O)(=O)N1CCC(CC1)Nc1ncc2ccc(=O)n([C@@H]3CCC[C@@H](O)C3)c2n1 |r| Show InChI InChI=1S/C19H27N5O4S/c1-29(27,28)23-9-7-14(8-10-23)21-19-20-12-13-5-6-17(26)24(18(13)22-19)15-3-2-4-16(25)11-15/h5-6,12,14-16,25H,2-4,7-11H2,1H3,(H,20,21,22)/t15-,16-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.43	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The purpose CDK4/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...				US Patent US10800783 (2020)
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 (Homo sapiens (Human))	BDBM370114 (8-[(1R,3R)-3-hydroxycyclohexyl]-2-{[1-(methylsulfo...) Show SMILES CS(=O)(=O)N1CCC(CC1)Nc1ncc2ccc(=O)n([C@@H]3CCC[C@@H](O)C3)c2n1 |r| Show InChI InChI=1S/C19H27N5O4S/c1-29(27,28)23-9-7-14(8-10-23)21-19-20-12-13-5-6-17(26)24(18(13)22-19)15-3-2-4-16(25)11-15/h5-6,12,14-16,25H,2-4,7-11H2,1H3,(H,20,21,22)/t15-,16-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.43	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CNRS					Assay Description The purpose CDK4/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...				J Med Chem 45: 1477-86 (2002) BindingDB Entry DOI: 10.7270/Q2FX7CSG
					More data for this Ligand-Target Pair