BDBM3714 2-{[3-({4-[(3-bromophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl}amino)propyl](2-hydroxyethyl)amino}ethan-1-ol::4-[(3-Bromophenyl)amino]-6-[[3-[N,N-bis(2-hydroxyethyl)amino]propyl]amino]pyrido[3,4-d]pyrimidine::PD158780 Analog 5r
SMILES: OCCN(CCO)CCCNc1cc2c(Nc3cccc(Br)c3)ncnc2cn1
InChI Key: InChIKey=YQPDGPGZDSDTPY-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM3714 (2-{[3-({4-[(3-bromophenyl)amino]pyrido[3,4-d]pyrim...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.350 | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of Auckland | Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe... | J Med Chem 41: 742-51 (1998) Article DOI: 10.1021/jm970641d BindingDB Entry DOI: 10.7270/Q2DB800T | |||||||||||
More data for this Ligand-Target Pair |