BDBM371507 1-Butyl-N-[1-(fluoromethyl)cyclopropyl]-3-[(1-methylpyrazol-4-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide::US10239843, Example 617

SMILES: CCCCn1c2ccc(cc2c(=O)n(Cc2cnn(C)c2)c1=O)S(=O)(=O)NC1(CF)CC1

InChI Key: InChIKey=DGYGOMJTENEMDQ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 371507   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ADP-ribose glycohydrolase ARH3 (Homo sapiens (Human))	BDBM371507 (1-Butyl-N-[1-(fluoromethyl)cyclopropyl]-3-[(1-meth...) Show SMILES CCCCn1c2ccc(cc2c(=O)n(Cc2cnn(C)c2)c1=O)S(=O)(=O)NC1(CF)CC1 Show InChI InChI=1S/C21H26FN5O4S/c1-3-4-9-26-18-6-5-16(32(30,31)24-21(14-22)7-8-21)10-17(18)19(28)27(20(26)29)13-15-11-23-25(2)12-15/h5-6,10-12,24H,3-4,7-9,13-14H2,1-2H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG) (Homo sapiens (Human))	BDBM371507 (1-Butyl-N-[1-(fluoromethyl)cyclopropyl]-3-[(1-meth...) Show SMILES CCCCn1c2ccc(cc2c(=O)n(Cc2cnn(C)c2)c1=O)S(=O)(=O)NC1(CF)CC1 Show InChI InChI=1S/C21H26FN5O4S/c1-3-4-9-26-18-6-5-16(32(30,31)24-21(14-22)7-8-21)10-17(18)19(28)27(20(26)29)13-15-11-23-25(2)12-15/h5-6,10-12,24H,3-4,7-9,13-14H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair