BDBM371639 (R)-4-(2-(2-Methylthiazol-4-yl)-4-(trifluoromethyl)phenyl)-N-(pyrimidin-2-yl)chroman-7-sulfonamide::US10239869, Example 64

SMILES: Cc1nc(cs1)-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1ncccn1)C(F)(F)F

InChI Key: InChIKey=WXVMQJKBDXCFTC-GOSISDBHSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 371639   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM371639 ((R)-4-(2-(2-Methylthiazol-4-yl)-4-(trifluoromethyl...) Show SMILES Cc1nc(cs1)-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1ncccn1)C(F)(F)F Show InChI InChI=1S/C24H19F3N4O3S2/c1-14-30-21(13-35-14)20-11-15(24(25,26)27)3-5-17(20)18-7-10-34-22-12-16(4-6-19(18)22)36(32,33)31-23-28-8-2-9-29-23/h2-6,8-9,11-13,18H,7,10H2,1H3,(H,28,29,31)/t18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California at San Francisco					Assay Description HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...				J Med Chem 51: 545-52 (2008) BindingDB Entry DOI: 10.7270/Q2NG4SZX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM371639 ((R)-4-(2-(2-Methylthiazol-4-yl)-4-(trifluoromethyl...) Show SMILES Cc1nc(cs1)-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1ncccn1)C(F)(F)F Show InChI InChI=1S/C24H19F3N4O3S2/c1-14-30-21(13-35-14)20-11-15(24(25,26)27)3-5-17(20)18-7-10-34-22-12-16(4-6-19(18)22)36(32,33)31-23-28-8-2-9-29-23/h2-6,8-9,11-13,18H,7,10H2,1H3,(H,28,29,31)/t18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
University of California at San Francisco					Assay Description HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...				J Med Chem 51: 545-52 (2008) BindingDB Entry DOI: 10.7270/Q2NG4SZX
					More data for this Ligand-Target Pair