BDBM371780 N-(6-fluoropyridin-2-yl)-4-(2-(6-methylpyridin-3-yl)-4-(trifluoromethyl)phenyl)chroman-7-sulfonamide::US10239869, Example 206

SMILES: Cc1ccc(cn1)-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1cccc(F)n1)C(F)(F)F

InChI Key: InChIKey=BCWBNSSZRLWCHD-OAQYLSRUSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 371780   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM371780 (N-(6-fluoropyridin-2-yl)-4-(2-(6-methylpyridin-3-y...) Show SMILES Cc1ccc(cn1)-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1cccc(F)n1)C(F)(F)F |r| Show InChI InChI=1S/C27H21F4N3O3S/c1-16-5-6-17(15-32-16)23-13-18(27(29,30)31)7-9-20(23)21-11-12-37-24-14-19(8-10-22(21)24)38(35,36)34-26-4-2-3-25(28)33-26/h2-10,13-15,21H,11-12H2,1H3,(H,33,34)/t21-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
University of California at San Francisco					Assay Description HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...				J Med Chem 51: 545-52 (2008) BindingDB Entry DOI: 10.7270/Q2NG4SZX
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha/beta-1/beta-2 (Homo sapiens (Human))	BDBM371780 (N-(6-fluoropyridin-2-yl)-4-(2-(6-methylpyridin-3-y...) Show SMILES Cc1ccc(cn1)-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1cccc(F)n1)C(F)(F)F |r| Show InChI InChI=1S/C27H21F4N3O3S/c1-16-5-6-17(15-32-16)23-13-18(27(29,30)31)7-9-20(23)21-11-12-37-24-14-19(8-10-22(21)24)38(35,36)34-26-4-2-3-25(28)33-26/h2-10,13-15,21H,11-12H2,1H3,(H,33,34)/t21-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	1.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lupin Ltd. Curated by ChEMBL					Assay Description Inhibition of Nav1.5 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...				J Med Chem 63: 6107-6133 (2020)
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM371780 (N-(6-fluoropyridin-2-yl)-4-(2-(6-methylpyridin-3-y...) Show SMILES Cc1ccc(cn1)-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1cccc(F)n1)C(F)(F)F |r| Show InChI InChI=1S/C27H21F4N3O3S/c1-16-5-6-17(15-32-16)23-13-18(27(29,30)31)7-9-20(23)21-11-12-37-24-14-19(8-10-22(21)24)38(35,36)34-26-4-2-3-25(28)33-26/h2-10,13-15,21H,11-12H2,1H3,(H,33,34)/t21-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
Lupin Ltd. Curated by ChEMBL					Assay Description Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...				J Med Chem 63: 6107-6133 (2020)
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM371780 (N-(6-fluoropyridin-2-yl)-4-(2-(6-methylpyridin-3-y...) Show SMILES Cc1ccc(cn1)-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1cccc(F)n1)C(F)(F)F |r| Show InChI InChI=1S/C27H21F4N3O3S/c1-16-5-6-17(15-32-16)23-13-18(27(29,30)31)7-9-20(23)21-11-12-37-24-14-19(8-10-22(21)24)38(35,36)34-26-4-2-3-25(28)33-26/h2-10,13-15,21H,11-12H2,1H3,(H,33,34)/t21-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California at San Francisco					Assay Description HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...				J Med Chem 51: 545-52 (2008) BindingDB Entry DOI: 10.7270/Q2NG4SZX
					More data for this Ligand-Target Pair