BDBM372159 6-(2,6- dimethylphenyl)- N-(3- morpholinophenyl)- 5H-pyrrolo[3,2- d ]pyrimidin-2- amine::US10239881, Example A12::US10875863, Example A12

SMILES: Cc1cccc(C)c1-c1cc2nc(Nc3cccc(c3)N3CCOCC3)ncc2[nH]1

InChI Key: InChIKey=ICKWVCXDMJAIEO-UHFFFAOYSA-N

Data: 2 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 372159   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM372159 (6-(2,6- dimethylphenyl)- N-(3- morpholinophenyl)- ...) Show SMILES Cc1cccc(C)c1-c1cc2nc(Nc3cccc(c3)N3CCOCC3)ncc2[nH]1 Show InChI InChI=1S/C24H25N5O/c1-16-5-3-6-17(2)23(16)21-14-20-22(27-21)15-25-24(28-20)26-18-7-4-8-19(13-18)29-9-11-30-12-10-29/h3-8,13-15,27H,9-12H2,1-2H3,(H,25,26,28)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY HEALTH NETWORK US Patent					Assay Description Active RIPK2 was purchased from Life Technologies as His-tagged of catalytic domain (amin acids 1-299) of human RIPK2 kinase expressed in insect cell...				US Patent US10875863 (2020)
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM372159 (6-(2,6- dimethylphenyl)- N-(3- morpholinophenyl)- ...) Show SMILES Cc1cccc(C)c1-c1cc2nc(Nc3cccc(c3)N3CCOCC3)ncc2[nH]1 Show InChI InChI=1S/C24H25N5O/c1-16-5-3-6-17(2)23(16)21-14-20-22(27-21)15-25-24(28-20)26-18-7-4-8-19(13-18)29-9-11-30-12-10-29/h3-8,13-15,27H,9-12H2,1-2H3,(H,25,26,28)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
National Taiwan University					Assay Description RIPK2 activity was measured using an indirect ELISA detection system. His—RIPK2 (0.6 nM) was incubated in the presence of 6 μM ATP (Sigma cat # ...				J Med Chem 51: 2795-806 (2008) BindingDB Entry DOI: 10.7270/Q289186K
					More data for this Ligand-Target Pair