BDBM3727 6-(Methylamino)-4-[(3-methylphenyl)amino]pyrido[3,4-d]pyrimidine::6-N-methyl-4-N-(3-methylphenyl)pyrido[3,4-d]pyrimidine-4,6-diamine::PD158780 Analog 9b

SMILES: CNc1cc2c(Nc3cccc(C)c3)ncnc2cn1

InChI Key: InChIKey=CCLWZSQAMSFYER-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 3727   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3727 (6-(Methylamino)-4-[(3-methylphenyl)amino]pyrido[3,...) Show SMILES CNc1cc2c(Nc3cccc(C)c3)ncnc2cn1 Show InChI InChI=1S/C15H15N5/c1-10-4-3-5-11(6-10)20-15-12-7-14(16-2)17-8-13(12)18-9-19-15/h3-9H,1-2H3,(H,16,17)(H,18,19,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.450	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 41: 742-51 (1998) Article DOI: 10.1021/jm970641d BindingDB Entry DOI: 10.7270/Q2DB800T
					More data for this Ligand-Target Pair