BDBM373086 1,3-bis(3-methyl-1- phenyl-1H-pyrazol- 5-yl)urea::US9896447, Compound 3

SMILES: Cc1cc(NC(=O)Nc2cc(C)nn2-c2ccccc2)n(n1)-c1ccccc1

InChI Key: InChIKey=UKCHVVKOGKUXAD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373086   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM373086 (1,3-bis(3-methyl-1- phenyl-1H-pyrazol- 5-yl)urea |...) Show SMILES Cc1cc(NC(=O)Nc2cc(C)nn2-c2ccccc2)n(n1)-c1ccccc1 Show InChI InChI=1S/C21H20N6O/c1-15-13-19(26(24-15)17-9-5-3-6-10-17)22-21(28)23-20-14-16(2)25-27(20)18-11-7-4-8-12-18/h3-14H,1-2H3,(H2,22,23,28)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
IRBM-MRL					Assay Description TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells are express TrkA receptor as a fusion with the we...				J Med Chem 51: 861-74 (2008) BindingDB Entry DOI: 10.7270/Q26975VH
					More data for this Ligand-Target Pair