BDBM373118 1,3-bis(2-methyl-4- phenyl-1,3-thiazol- 5-yl)urea::US9896447, Compound 35

SMILES: Cc1nc(c(NC(=O)Nc2sc(C)nc2-c2ccccc2)s1)-c1ccccc1

InChI Key: InChIKey=IZNYUHSMCAEIRI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373118   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM373118 (1,3-bis(2-methyl-4- phenyl-1,3-thiazol- 5-yl)urea ...) Show SMILES Cc1nc(c(NC(=O)Nc2sc(C)nc2-c2ccccc2)s1)-c1ccccc1 Show InChI InChI=1S/C21H18N4OS2/c1-13-22-17(15-9-5-3-6-10-15)19(27-13)24-21(26)25-20-18(23-14(2)28-20)16-11-7-4-8-12-16/h3-12H,1-2H3,(H2,24,25,26)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	610	n/a	n/a	n/a	n/a	n/a	n/a
IRBM-MRL					Assay Description TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells are express TrkA receptor as a fusion with the we...				J Med Chem 51: 861-74 (2008) BindingDB Entry DOI: 10.7270/Q26975VH
					More data for this Ligand-Target Pair