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Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM373118'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM373118
PNG
(1,3-bis(2-methyl-4- phenyl-1,3-thiazol- 5-yl)urea ...)
Show SMILES Cc1nc(c(NC(=O)Nc2sc(C)nc2-c2ccccc2)s1)-c1ccccc1
Show InChI InChI=1S/C21H18N4OS2/c1-13-22-17(15-9-5-3-6-10-15)19(27-13)24-21(26)25-20-18(23-14(2)28-20)16-11-7-4-8-12-16/h3-12H,1-2H3,(H2,24,25,26)
PDB
MMDB

UniProtKB/SwissProt

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PC cid
PC sid
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n/an/a 610n/an/an/an/an/an/a



IRBM-MRL



Assay Description
TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells are express TrkA receptor as a fusion with the we...

J Med Chem 51: 861-74 (2008)


BindingDB Entry DOI: 10.7270/Q26975VH
More data for this
Ligand-Target Pair