BDBM373262 FD-2013031::US9902709, Compound Example 6

SMILES: Cn1cc(cn1)-c1nccc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)c1N

InChI Key: InChIKey=KCUAYVYWUKSJHN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373262   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM373262 (FD-2013031 | US9902709, Compound Example 6) Show SMILES Cn1cc(cn1)-c1nccc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)c1N Show InChI InChI=1S/C23H18ClF3N6O2/c1-33-12-13(11-30-33)21-20(28)19(8-9-29-21)35-16-5-2-14(3-6-16)31-22(34)32-15-4-7-18(24)17(10-15)23(25,26)27/h2-12H,28H2,1H3,(H2,31,32,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	215	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description Kinase Enzymatic step assay Control (10 μL) Sample Negative Positive Compound 4 μL 4 μL 2.5% 4 μL 2.5% DMSO/kinase DMSO/kinase bu...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2T43WF5
					More data for this Ligand-Target Pair