BDBM373566 US9902710, Compound 48

SMILES: COc1cc2cncc(Cc3ccc4nc(C)ccc4n3)c2cc1OC

InChI Key: InChIKey=JSXQAIGUALZPGT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373566   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM373566 (US9902710, Compound 48) Show SMILES COc1cc2cncc(Cc3ccc4nc(C)ccc4n3)c2cc1OC Show InChI InChI=1S/C21H19N3O2/c1-13-4-6-19-18(23-13)7-5-16(24-19)8-14-11-22-12-15-9-20(25-2)21(26-3)10-17(14)15/h4-7,9-12H,8H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair