BDBM373685 US9902710, Compound 160

SMILES: CCCc1ncc(Cc2ccc3cccc(NC(=O)CN)c3n2)c2cc(OC)c(OC)cc12

InChI Key: InChIKey=KBXGASYJJKKANN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373685   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM373685 (US9902710, Compound 160) Show SMILES CCCc1ncc(Cc2ccc3cccc(NC(=O)CN)c3n2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H28N4O3/c1-4-6-21-20-13-24(33-3)23(32-2)12-19(20)17(15-28-21)11-18-10-9-16-7-5-8-22(26(16)29-18)30-25(31)14-27/h5,7-10,12-13,15H,4,6,11,14,27H2,1-3H3,(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair