null
SMILES: FC(F)c1cccc(CN2CCC(CC2)Oc2ccc(cc2Cl)S(=O)(=O)Nc2nccs2)c1
InChI Key: InChIKey=NZDSIPOBKQVWOJ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM373744 (3-chloro-4-((1-(3-(difluoromethyl)benzyl)piperidin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 253 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which... | J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM373744 (3-chloro-4-((1-(3-(difluoromethyl)benzyl)piperidin...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which... | J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human)) | BDBM373744 (3-chloro-4-((1-(3-(difluoromethyl)benzyl)piperidin...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which... | J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM373744 (3-chloro-4-((1-(3-(difluoromethyl)benzyl)piperidin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and... | J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human)) | BDBM373744 (3-chloro-4-((1-(3-(difluoromethyl)benzyl)piperidin...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.21E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and... | J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM373744 (3-chloro-4-((1-(3-(difluoromethyl)benzyl)piperidin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals Inc. US Patent | Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ... | US Patent US10662184 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human)) | BDBM373744 (3-chloro-4-((1-(3-(difluoromethyl)benzyl)piperidin...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 7.21E+3 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM373744 (3-chloro-4-((1-(3-(difluoromethyl)benzyl)piperidin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 253 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals Inc. US Patent | Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma... | US Patent US10815229 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM373744 (3-chloro-4-((1-(3-(difluoromethyl)benzyl)piperidin...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals Inc. US Patent | Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma... | US Patent US10815229 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human)) | BDBM373744 (3-chloro-4-((1-(3-(difluoromethyl)benzyl)piperidin...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals Inc. US Patent | Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma... | US Patent US10815229 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM373744 (3-chloro-4-((1-(3-(difluoromethyl)benzyl)piperidin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals Inc. US Patent | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and... | US Patent US10815229 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human)) | BDBM373744 (3-chloro-4-((1-(3-(difluoromethyl)benzyl)piperidin...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.21E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals Inc. US Patent | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and... | US Patent US10815229 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM373744 (3-chloro-4-((1-(3-(difluoromethyl)benzyl)piperidin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human)) | BDBM373744 (3-chloro-4-((1-(3-(difluoromethyl)benzyl)piperidin...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.21E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals Inc. US Patent | Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ... | US Patent US10662184 (2020) | |||||||||||
More data for this Ligand-Target Pair |