BDBM373816 (S)-3-chloro-4-(methyl(1-(3-methylbenzyl)pyrrolidin-3-yl)amino)-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide::US10246453, Example 83::US10815229, Example 83

SMILES: CN([C@H]1CCN(Cc2cccc(C)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1

InChI Key: InChIKey=NKZGMZNRCSCYRF-KRWDZBQOSA-N

Data: 10 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 373816   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373816 ((S)-3-chloro-4-(methyl(1-(3-methylbenzyl)pyrrolidi...) Show SMILES CN([C@H]1CCN(Cc2cccc(C)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C21H24ClN5O2S2/c1-15-4-3-5-16(10-15)12-27-9-8-17(13-27)26(2)20-7-6-18(11-19(20)22)31(28,29)25-21-23-14-24-30-21/h3-7,10-11,14,17H,8-9,12-13H2,1-2H3,(H,23,24,25)/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM373816 ((S)-3-chloro-4-(methyl(1-(3-methylbenzyl)pyrrolidi...) Show SMILES CN([C@H]1CCN(Cc2cccc(C)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C21H24ClN5O2S2/c1-15-4-3-5-16(10-15)12-27-9-8-17(13-27)26(2)20-7-6-18(11-19(20)22)31(28,29)25-21-23-14-24-30-21/h3-7,10-11,14,17H,8-9,12-13H2,1-2H3,(H,23,24,25)/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel alpha subunit (Homo sapiens (Human))	BDBM373816 ((S)-3-chloro-4-(methyl(1-(3-methylbenzyl)pyrrolidi...) Show SMILES CN([C@H]1CCN(Cc2cccc(C)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C21H24ClN5O2S2/c1-15-4-3-5-16(10-15)12-27-9-8-17(13-27)26(2)20-7-6-18(11-19(20)22)31(28,29)25-21-23-14-24-30-21/h3-7,10-11,14,17H,8-9,12-13H2,1-2H3,(H,23,24,25)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373816 ((S)-3-chloro-4-(methyl(1-(3-methylbenzyl)pyrrolidi...) Show SMILES CN([C@H]1CCN(Cc2cccc(C)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C21H24ClN5O2S2/c1-15-4-3-5-16(10-15)12-27-9-8-17(13-27)26(2)20-7-6-18(11-19(20)22)31(28,29)25-21-23-14-24-30-21/h3-7,10-11,14,17H,8-9,12-13H2,1-2H3,(H,23,24,25)/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel alpha subunit (Homo sapiens (Human))	BDBM373816 ((S)-3-chloro-4-(methyl(1-(3-methylbenzyl)pyrrolidi...) Show SMILES CN([C@H]1CCN(Cc2cccc(C)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C21H24ClN5O2S2/c1-15-4-3-5-16(10-15)12-27-9-8-17(13-27)26(2)20-7-6-18(11-19(20)22)31(28,29)25-21-23-14-24-30-21/h3-7,10-11,14,17H,8-9,12-13H2,1-2H3,(H,23,24,25)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...				US Patent US10815229 (2020)
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373816 ((S)-3-chloro-4-(methyl(1-(3-methylbenzyl)pyrrolidi...) Show SMILES CN([C@H]1CCN(Cc2cccc(C)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C21H24ClN5O2S2/c1-15-4-3-5-16(10-15)12-27-9-8-17(13-27)26(2)20-7-6-18(11-19(20)22)31(28,29)25-21-23-14-24-30-21/h3-7,10-11,14,17H,8-9,12-13H2,1-2H3,(H,23,24,25)/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...				US Patent US10815229 (2020)
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM373816 ((S)-3-chloro-4-(methyl(1-(3-methylbenzyl)pyrrolidi...) Show SMILES CN([C@H]1CCN(Cc2cccc(C)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C21H24ClN5O2S2/c1-15-4-3-5-16(10-15)12-27-9-8-17(13-27)26(2)20-7-6-18(11-19(20)22)31(28,29)25-21-23-14-24-30-21/h3-7,10-11,14,17H,8-9,12-13H2,1-2H3,(H,23,24,25)/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...				US Patent US10815229 (2020)
					More data for this Ligand-Target Pair
Sodium channel alpha subunit (Homo sapiens (Human))	BDBM373816 ((S)-3-chloro-4-(methyl(1-(3-methylbenzyl)pyrrolidi...) Show SMILES CN([C@H]1CCN(Cc2cccc(C)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C21H24ClN5O2S2/c1-15-4-3-5-16(10-15)12-27-9-8-17(13-27)26(2)20-7-6-18(11-19(20)22)31(28,29)25-21-23-14-24-30-21/h3-7,10-11,14,17H,8-9,12-13H2,1-2H3,(H,23,24,25)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...				US Patent US10815229 (2020)
					More data for this Ligand-Target Pair
ep nav1.6 (Homo sapiens (Human))	BDBM373816 ((S)-3-chloro-4-(methyl(1-(3-methylbenzyl)pyrrolidi...) Show SMILES CN([C@H]1CCN(Cc2cccc(C)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C21H24ClN5O2S2/c1-15-4-3-5-16(10-15)12-27-9-8-17(13-27)26(2)20-7-6-18(11-19(20)22)31(28,29)25-21-23-14-24-30-21/h3-7,10-11,14,17H,8-9,12-13H2,1-2H3,(H,23,24,25)/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...				US Patent US10815229 (2020)
					More data for this Ligand-Target Pair
Sodium channel alpha subunit (Homo sapiens (Human))	BDBM373816 ((S)-3-chloro-4-(methyl(1-(3-methylbenzyl)pyrrolidi...) Show SMILES CN([C@H]1CCN(Cc2cccc(C)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C21H24ClN5O2S2/c1-15-4-3-5-16(10-15)12-27-9-8-17(13-27)26(2)20-7-6-18(11-19(20)22)31(28,29)25-21-23-14-24-30-21/h3-7,10-11,14,17H,8-9,12-13H2,1-2H3,(H,23,24,25)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair