BDBM373821 (R)-5-chloro-2-fluoro-4-(1-(3-methylbenzyl)pyrrolidin-3-ylamino)-N-(thiazol-2-yl)benzenesulfonamide::US10246453, Example 88::US10815229, Example 88

SMILES: Cc1cccc(CN2CC[C@H](C2)Nc2cc(F)c(cc2Cl)S(=O)(=O)Nc2nccs2)c1

InChI Key: InChIKey=SNOOPGKUOHRVSG-MRXNPFEDSA-N

Data: 10 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 373821   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373821 ((R)-5-chloro-2-fluoro-4-(1-(3-methylbenzyl)pyrroli...) Show SMILES Cc1cccc(CN2CC[C@H](C2)Nc2cc(F)c(cc2Cl)S(=O)(=O)Nc2nccs2)c1 Show InChI InChI=1S/C21H22ClFN4O2S2/c1-14-3-2-4-15(9-14)12-27-7-5-16(13-27)25-19-11-18(23)20(10-17(19)22)31(28,29)26-21-24-6-8-30-21/h2-4,6,8-11,16,25H,5,7,12-13H2,1H3,(H,24,26)/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	381	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM373821 ((R)-5-chloro-2-fluoro-4-(1-(3-methylbenzyl)pyrroli...) Show SMILES Cc1cccc(CN2CC[C@H](C2)Nc2cc(F)c(cc2Cl)S(=O)(=O)Nc2nccs2)c1 Show InChI InChI=1S/C21H22ClFN4O2S2/c1-14-3-2-4-15(9-14)12-27-7-5-16(13-27)25-19-11-18(23)20(10-17(19)22)31(28,29)26-21-24-6-8-30-21/h2-4,6,8-11,16,25H,5,7,12-13H2,1H3,(H,24,26)/t16-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.91E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel alpha subunit (Homo sapiens (Human))	BDBM373821 ((R)-5-chloro-2-fluoro-4-(1-(3-methylbenzyl)pyrroli...) Show SMILES Cc1cccc(CN2CC[C@H](C2)Nc2cc(F)c(cc2Cl)S(=O)(=O)Nc2nccs2)c1 Show InChI InChI=1S/C21H22ClFN4O2S2/c1-14-3-2-4-15(9-14)12-27-7-5-16(13-27)25-19-11-18(23)20(10-17(19)22)31(28,29)26-21-24-6-8-30-21/h2-4,6,8-11,16,25H,5,7,12-13H2,1H3,(H,24,26)/t16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373821 ((R)-5-chloro-2-fluoro-4-(1-(3-methylbenzyl)pyrroli...) Show SMILES Cc1cccc(CN2CC[C@H](C2)Nc2cc(F)c(cc2Cl)S(=O)(=O)Nc2nccs2)c1 Show InChI InChI=1S/C21H22ClFN4O2S2/c1-14-3-2-4-15(9-14)12-27-7-5-16(13-27)25-19-11-18(23)20(10-17(19)22)31(28,29)26-21-24-6-8-30-21/h2-4,6,8-11,16,25H,5,7,12-13H2,1H3,(H,24,26)/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel alpha subunit (Homo sapiens (Human))	BDBM373821 ((R)-5-chloro-2-fluoro-4-(1-(3-methylbenzyl)pyrroli...) Show SMILES Cc1cccc(CN2CC[C@H](C2)Nc2cc(F)c(cc2Cl)S(=O)(=O)Nc2nccs2)c1 Show InChI InChI=1S/C21H22ClFN4O2S2/c1-14-3-2-4-15(9-14)12-27-7-5-16(13-27)25-19-11-18(23)20(10-17(19)22)31(28,29)26-21-24-6-8-30-21/h2-4,6,8-11,16,25H,5,7,12-13H2,1H3,(H,24,26)/t16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...				US Patent US10815229 (2020)
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373821 ((R)-5-chloro-2-fluoro-4-(1-(3-methylbenzyl)pyrroli...) Show SMILES Cc1cccc(CN2CC[C@H](C2)Nc2cc(F)c(cc2Cl)S(=O)(=O)Nc2nccs2)c1 Show InChI InChI=1S/C21H22ClFN4O2S2/c1-14-3-2-4-15(9-14)12-27-7-5-16(13-27)25-19-11-18(23)20(10-17(19)22)31(28,29)26-21-24-6-8-30-21/h2-4,6,8-11,16,25H,5,7,12-13H2,1H3,(H,24,26)/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	381	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...				US Patent US10815229 (2020)
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM373821 ((R)-5-chloro-2-fluoro-4-(1-(3-methylbenzyl)pyrroli...) Show SMILES Cc1cccc(CN2CC[C@H](C2)Nc2cc(F)c(cc2Cl)S(=O)(=O)Nc2nccs2)c1 Show InChI InChI=1S/C21H22ClFN4O2S2/c1-14-3-2-4-15(9-14)12-27-7-5-16(13-27)25-19-11-18(23)20(10-17(19)22)31(28,29)26-21-24-6-8-30-21/h2-4,6,8-11,16,25H,5,7,12-13H2,1H3,(H,24,26)/t16-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.91E+3	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...				US Patent US10815229 (2020)
					More data for this Ligand-Target Pair
Sodium channel alpha subunit (Homo sapiens (Human))	BDBM373821 ((R)-5-chloro-2-fluoro-4-(1-(3-methylbenzyl)pyrroli...) Show SMILES Cc1cccc(CN2CC[C@H](C2)Nc2cc(F)c(cc2Cl)S(=O)(=O)Nc2nccs2)c1 Show InChI InChI=1S/C21H22ClFN4O2S2/c1-14-3-2-4-15(9-14)12-27-7-5-16(13-27)25-19-11-18(23)20(10-17(19)22)31(28,29)26-21-24-6-8-30-21/h2-4,6,8-11,16,25H,5,7,12-13H2,1H3,(H,24,26)/t16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...				US Patent US10815229 (2020)
					More data for this Ligand-Target Pair
ep nav1.6 (Homo sapiens (Human))	BDBM373821 ((R)-5-chloro-2-fluoro-4-(1-(3-methylbenzyl)pyrroli...) Show SMILES Cc1cccc(CN2CC[C@H](C2)Nc2cc(F)c(cc2Cl)S(=O)(=O)Nc2nccs2)c1 Show InChI InChI=1S/C21H22ClFN4O2S2/c1-14-3-2-4-15(9-14)12-27-7-5-16(13-27)25-19-11-18(23)20(10-17(19)22)31(28,29)26-21-24-6-8-30-21/h2-4,6,8-11,16,25H,5,7,12-13H2,1H3,(H,24,26)/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...				US Patent US10815229 (2020)
					More data for this Ligand-Target Pair
Sodium channel alpha subunit (Homo sapiens (Human))	BDBM373821 ((R)-5-chloro-2-fluoro-4-(1-(3-methylbenzyl)pyrroli...) Show SMILES Cc1cccc(CN2CC[C@H](C2)Nc2cc(F)c(cc2Cl)S(=O)(=O)Nc2nccs2)c1 Show InChI InChI=1S/C21H22ClFN4O2S2/c1-14-3-2-4-15(9-14)12-27-7-5-16(13-27)25-19-11-18(23)20(10-17(19)22)31(28,29)26-21-24-6-8-30-21/h2-4,6,8-11,16,25H,5,7,12-13H2,1H3,(H,24,26)/t16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair