BDBM374626 1-(1-(2,4-Dichlorophenyl)ethyl)-6-(3′-ethyl-[1,4′-bipiperidin]-1′-yl)-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile 2,2,2-trifluoroacetate::US10246462, Example 7

SMILES: CCC1CN(CCC1N1CCCCC1)c1cnc2c(nn(C(C)c3ccc(Cl)cc3Cl)c2n1)C#N

InChI Key: InChIKey=ZAHCYMHFSRMAIT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 374626   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM374626 (1-(1-(2,4-Dichlorophenyl)ethyl)-6-(3′-ethyl-...) Show SMILES CCC1CN(CCC1N1CCCCC1)c1cnc2c(nn(C(C)c3ccc(Cl)cc3Cl)c2n1)C#N Show InChI InChI=1S/C26H31Cl2N7/c1-3-18-16-34(12-9-23(18)33-10-5-4-6-11-33)24-15-30-25-22(14-29)32-35(26(25)31-24)17(2)20-8-7-19(27)13-21(20)28/h7-8,13,15,17-18,23H,3-6,9-12,16H2,1-2H3	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q24F1T13
					More data for this Ligand-Target Pair