BDBM374639 1-((R)-1-(2,4-Dichlorophenyl)ethyl)-3-methyl-6-((3R,4S)-3-methyl-4-((R)-2-methylpyrrolidin-1-yl)piperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazine hydrochloride::US10246462, Example 20
SMILES: C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC[C@@H]([C@H](C)C1)N1CCC[C@H]1C
InChI Key: InChIKey=MHYORVPBRVOLMW-MUUPZMKNSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
C-C chemokine receptor type 4 (Homo sapiens (Human)) | BDBM374639 (1-((R)-1-(2,4-Dichlorophenyl)ethyl)-3-methyl-6-((3...) | UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to... | J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q24F1T13 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 4 (Homo sapiens (Human)) | BDBM374639 (1-((R)-1-(2,4-Dichlorophenyl)ethyl)-3-methyl-6-((3...) | UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
RAPT Therapeutics Curated by ChEMBL | Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv... | J Med Chem 62: 6190-6213 (2019) Article DOI: 10.1021/acs.jmedchem.9b00506 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 4 (Homo sapiens (Human)) | BDBM374639 (1-((R)-1-(2,4-Dichlorophenyl)ethyl)-3-methyl-6-((3...) | UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 381 | n/a | n/a | n/a | n/a | n/a | n/a |
RAPT Therapeutics Curated by ChEMBL | Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated... | J Med Chem 62: 6190-6213 (2019) Article DOI: 10.1021/acs.jmedchem.9b00506 | |||||||||||
More data for this Ligand-Target Pair |