BDBM374645 1-(1-(2,4-Dichlorophenyl)ethyl)-6-(3′-fluoro-[1,4′-bipiperidin]-1′-yl)-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile 2,2,2-trifluoroacetate::US10246462, Example 26

SMILES: CC(c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CCC(C(F)C1)N1CCCCC1

InChI Key: InChIKey=RPIUWDUUKZGNET-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 374645   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM374645 (1-(1-(2,4-Dichlorophenyl)ethyl)-6-(3′-fluoro...) Show SMILES CC(c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CCC(C(F)C1)N1CCCCC1 Show InChI InChI=1S/C24H26Cl2FN7/c1-15(17-6-5-16(25)11-18(17)26)34-24-23(20(12-28)31-34)29-13-22(30-24)33-10-7-21(19(27)14-33)32-8-3-2-4-9-32/h5-6,11,13,15,19,21H,2-4,7-10,14H2,1H3	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>500	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q24F1T13
					More data for this Ligand-Target Pair