BDBM374653 ((3R,4S)-1-(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)-3-methylpiperidin-4-yl)-L-proline 2,2,2-trifluoroacetate::US10246462, Example 34

SMILES: C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC[C@@H]([C@H](C)C1)N1CCC[C@H]1C(O)=O

InChI Key: InChIKey=NHGVWCUJKHRCDI-GNBIQWSPSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 374653   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM374653 (((3R,4S)-1-(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-3-...) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC[C@@H]([C@H](C)C1)N1CCC[C@H]1C(O)=O |r| Show InChI InChI=1S/C25H30Cl2N6O2/c1-14-13-31(10-8-20(14)32-9-4-5-21(32)25(34)35)22-12-28-23-15(2)30-33(24(23)29-22)16(3)18-7-6-17(26)11-19(18)27/h6-7,11-12,14,16,20-21H,4-5,8-10,13H2,1-3H3,(H,34,35)/t14-,16-,20+,21+/m1/s1	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 62: 6190-6213 (2019) Article DOI: 10.1021/acs.jmedchem.9b00506
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM374653 (((3R,4S)-1-(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-3-...) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC[C@@H]([C@H](C)C1)N1CCC[C@H]1C(O)=O |r| Show InChI InChI=1S/C25H30Cl2N6O2/c1-14-13-31(10-8-20(14)32-9-4-5-21(32)25(34)35)22-12-28-23-15(2)30-33(24(23)29-22)16(3)18-7-6-17(26)11-19(18)27/h6-7,11-12,14,16,20-21H,4-5,8-10,13H2,1-3H3,(H,34,35)/t14-,16-,20+,21+/m1/s1	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>500	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q24F1T13
					More data for this Ligand-Target Pair