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BDBM374669 3-((2S)-1-((2S)-1-(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)-2-methylpiperidin-4-yl)pyrrolidin-2-yl)propanoic acid 2,2,2-trifluoroacetate::US10246462, Example 50

SMILES: C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CCC(C[C@@H]1C)N1CCC[C@H]1CCC(O)=O

InChI Key: InChIKey=LSWIJTRDSHUWCF-XPIIAJOSSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 374669   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
C-C chemokine receptor type 4


(Homo sapiens (Human))		BDBM374669
PNG
(3-((2S)-1-((2S)-1-(1-((R)-1-(2,4-Dichlorophenyl)et...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CCC(C[C@@H]1C)N1CCC[C@H]1CCC(O)=O |r|
Show InChI InChI=1S/C27H34Cl2N6O2/c1-16-13-21(34-11-4-5-20(34)7-9-25(36)37)10-12-33(16)24-15-30-26-17(2)32-35(27(26)31-24)18(3)22-8-6-19(28)14-23(22)29/h6,8,14-16,18,20-21H,4-5,7,9-13H2,1-3H3,(H,36,37)/t16-,18+,20-,21?/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

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PC cid
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UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



St. Jude Research Hospital



Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...

J Med Chem 50: 1876-85 (2007)


BindingDB Entry DOI: 10.7270/Q24F1T13
More data for this
Ligand-Target Pair