BDBM374690 3-((S)-1-((1S,6R)-4-(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)-6-methylcyclohex-3-en-1-yl)pyrrolidin-2-yl)propanoic acid hydrochloride::US10246462, Example 71::US10246462, Example 72::US10246462, Example 77

SMILES: C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)C1=CCC([C@H](C)C1)N1CCC[C@H]1CCC(O)=O

InChI Key: InChIKey=BTIYILIGTINKCG-GAIYTWNRSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 374690   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM374690 (3-((S)-1-((1S,6R)-4-(1-((R)-1-(2,4-Dichlorophenyl)...) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)C1=CCC([C@H](C)C1)N1CCC[C@H]1CCC(O)=O |r,t:23| Show InChI InChI=1S/C28H33Cl2N5O2/c1-16-13-19(6-10-25(16)34-12-4-5-21(34)8-11-26(36)37)24-15-31-27-17(2)33-35(28(27)32-24)18(3)22-9-7-20(29)14-23(22)30/h6-7,9,14-16,18,21,25H,4-5,8,10-13H2,1-3H3,(H,36,37)/t16-,18-,21+,25?/m1/s1	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q24F1T13
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM374690 (3-((S)-1-((1S,6R)-4-(1-((R)-1-(2,4-Dichlorophenyl)...) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)C1=CCC([C@H](C)C1)N1CCC[C@H]1CCC(O)=O |r,t:23| Show InChI InChI=1S/C28H33Cl2N5O2/c1-16-13-19(6-10-25(16)34-12-4-5-21(34)8-11-26(36)37)24-15-31-27-17(2)33-35(28(27)32-24)18(3)22-9-7-20(29)14-23(22)30/h6-7,9,14-16,18,21,25H,4-5,8,10-13H2,1-3H3,(H,36,37)/t16-,18-,21+,25?/m1/s1	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q24F1T13
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM374690 (3-((S)-1-((1S,6R)-4-(1-((R)-1-(2,4-Dichlorophenyl)...) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)C1=CCC([C@H](C)C1)N1CCC[C@H]1CCC(O)=O |r,t:23| Show InChI InChI=1S/C28H33Cl2N5O2/c1-16-13-19(6-10-25(16)34-12-4-5-21(34)8-11-26(36)37)24-15-31-27-17(2)33-35(28(27)32-24)18(3)22-9-7-20(29)14-23(22)30/h6-7,9,14-16,18,21,25H,4-5,8,10-13H2,1-3H3,(H,36,37)/t16-,18-,21+,25?/m1/s1	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>500	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q24F1T13
					More data for this Ligand-Target Pair