BDBM374720 14-methyl-6,7,13,14-tetrahydro-1,15- ethenopyrazolo[4,3- f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one::US10246466, Example 49::US10618912, Example 49

SMILES: CN1Cc2ccccc2OCCNC(=O)c2cnn3ccc1nc23

InChI Key: InChIKey=HQXVNKKSTUDRSP-UHFFFAOYSA-N

Data: 4 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 374720   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM374720 (14-methyl-6,7,13,14-tetrahydro-1,15- ethenopyrazol...) Show SMILES CN1Cc2ccccc2OCCNC(=O)c2cnn3ccc1nc23 Show InChI InChI=1S/C17H17N5O2/c1-21-11-12-4-2-3-5-14(12)24-9-7-18-17(23)13-10-19-22-8-6-15(21)20-16(13)22/h2-6,8,10H,7,9,11H2,1H3,(H,18,23)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q20P12B6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM374720 (14-methyl-6,7,13,14-tetrahydro-1,15- ethenopyrazol...) Show SMILES CN1Cc2ccccc2OCCNC(=O)c2cnn3ccc1nc23 Show InChI InChI=1S/C17H17N5O2/c1-21-11-12-4-2-3-5-14(12)24-9-7-18-17(23)13-10-19-22-8-6-15(21)20-16(13)22/h2-6,8,10H,7,9,11H2,1H3,(H,18,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a
Turning Point Therapeutics, Inc. US Patent					Assay Description Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...				US Patent US10618912 (2020)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM374720 (14-methyl-6,7,13,14-tetrahydro-1,15- ethenopyrazol...) Show SMILES CN1Cc2ccccc2OCCNC(=O)c2cnn3ccc1nc23 Show InChI InChI=1S/C17H17N5O2/c1-21-11-12-4-2-3-5-14(12)24-9-7-18-17(23)13-10-19-22-8-6-15(21)20-16(13)22/h2-6,8,10H,7,9,11H2,1H3,(H,18,23)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a
Turning Point Therapeutics, Inc. US Patent					Assay Description Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...				US Patent US10618912 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM374720 (14-methyl-6,7,13,14-tetrahydro-1,15- ethenopyrazol...) Show SMILES CN1Cc2ccccc2OCCNC(=O)c2cnn3ccc1nc23 Show InChI InChI=1S/C17H17N5O2/c1-21-11-12-4-2-3-5-14(12)24-9-7-18-17(23)13-10-19-22-8-6-15(21)20-16(13)22/h2-6,8,10H,7,9,11H2,1H3,(H,18,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q20P12B6
					More data for this Ligand-Target Pair