null
SMILES: CC1Nc2ccn3ncc(C(=O)NCCOc4ccc(F)cc14)c3n2
InChI Key: InChIKey=TTWJGJUDRLYONZ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM374722 (11-fluoro-13-methyl-6,7,13,14-tetrahydro-1,15- eth...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.0650 | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio... | J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q20P12B6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM374722 (11-fluoro-13-methyl-6,7,13,14-tetrahydro-1,15- eth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio... | J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q20P12B6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM374722 (11-fluoro-13-methyl-6,7,13,14-tetrahydro-1,15- eth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio... | J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q20P12B6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM374722 (11-fluoro-13-methyl-6,7,13,14-tetrahydro-1,15- eth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a |
Turning Point Therapeutics, Inc. US Patent | Assay Description Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio... | US Patent US10618912 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM374722 (11-fluoro-13-methyl-6,7,13,14-tetrahydro-1,15- eth...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.0650 | n/a | n/a | n/a | n/a | n/a |
Turning Point Therapeutics, Inc. US Patent | Assay Description Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio... | US Patent US10618912 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM374722 (11-fluoro-13-methyl-6,7,13,14-tetrahydro-1,15- eth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a |
Turning Point Therapeutics, Inc. US Patent | Assay Description Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio... | US Patent US10618912 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM374722 (11-fluoro-13-methyl-6,7,13,14-tetrahydro-1,15- eth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a |
Turning Point Therapeutics, Inc. US Patent | Assay Description Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio... | US Patent US10618912 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM374722 (11-fluoro-13-methyl-6,7,13,14-tetrahydro-1,15- eth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio... | J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q20P12B6 | |||||||||||
More data for this Ligand-Target Pair |