null

SMILES: Cc1cc2nn3[C@@H]4[C@H](COc3c2cc1C(O)=O)N(CC1CC1)[C@]1([C@H]4c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12

InChI Key: InChIKey=MEPNXWGZCBHNAI-NCRFVDKVSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 374792   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM374792 (US10246467, Example I-112 | US10919913, # I-112) Show SMILES Cc1cc2nn3[C@@H]4[C@H](COc3c2cc1C(O)=O)N(CC1CC1)[C@]1([C@H]4c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12 |r| Show InChI InChI=1S/C31H25Cl2FN4O4/c1-14-9-22-19(11-18(14)29(39)40)28-38(36-22)27-24(13-42-28)37(12-15-5-6-15)31(25(27)17-3-2-4-21(33)26(17)34)20-8-7-16(32)10-23(20)35-30(31)41/h2-4,7-11,15,24-25,27H,5-6,12-13H2,1H3,(H,35,41)(H,39,40)/t24-,25-,27+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				US Patent US10919913 (2021)
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374792 (US10246467, Example I-112 | US10919913, # I-112) Show SMILES Cc1cc2nn3[C@@H]4[C@H](COc3c2cc1C(O)=O)N(CC1CC1)[C@]1([C@H]4c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12 |r| Show InChI InChI=1S/C31H25Cl2FN4O4/c1-14-9-22-19(11-18(14)29(39)40)28-38(36-22)27-24(13-42-28)37(12-15-5-6-15)31(25(27)17-3-2-4-21(33)26(17)34)20-8-7-16(32)10-23(20)35-30(31)41/h2-4,7-11,15,24-25,27H,5-6,12-13H2,1H3,(H,35,41)(H,39,40)/t24-,25-,27+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair