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SMILES: Cc1cc(ccn1)-c1ncc(CC(=O)Nc2ccc(cn2)-c2ccccn2)cc1C

InChI Key: InChIKey=YCXIDNDPJQCJSR-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 374916   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Wnt-3a (Homo sapiens (Human))	BDBM374916 (N-(2,3'-bipyridin-6'-yl)-2-(2',3-dimethyl-2,4'-bip...) Show SMILES Cc1cc(ccn1)-c1ncc(CC(=O)Nc2ccc(cn2)-c2ccccn2)cc1C Show InChI InChI=1S/C24H21N5O/c1-16-11-18(14-28-24(16)19-8-10-25-17(2)12-19)13-23(30)29-22-7-6-20(15-27-22)21-5-3-4-9-26-21/h3-12,14-15H,13H2,1-2H3,(H,27,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...				J Med Chem 50: 5727-34 (2007) BindingDB Entry DOI: 10.7270/Q2GM89KJ
					More data for this Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine (Mus musculus)	BDBM374916 (N-(2,3'-bipyridin-6'-yl)-2-(2',3-dimethyl-2,4'-bip...) Show SMILES Cc1cc(ccn1)-c1ncc(CC(=O)Nc2ccc(cn2)-c2ccccn2)cc1C Show InChI InChI=1S/C24H21N5O/c1-16-11-18(14-28-24(16)19-8-10-25-17(2)12-19)13-23(30)29-22-7-6-20(15-27-22)21-5-3-4-9-26-21/h3-12,14-15H,13H2,1-2H3,(H,27,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of PORCN in mouse Leydig cells overexpressing Wnt3A co-cultured with TM3 cells transfected with Wnt-luciferase gene after 24 hrs by lumine...				ACS Med Chem Lett 7: 676-80 (2016) Article DOI: 10.1021/acsmedchemlett.6b00038
					More data for this Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine (Mus musculus)	BDBM374916 (N-(2,3'-bipyridin-6'-yl)-2-(2',3-dimethyl-2,4'-bip...) Show SMILES Cc1cc(ccn1)-c1ncc(CC(=O)Nc2ccc(cn2)-c2ccccn2)cc1C Show InChI InChI=1S/C24H21N5O/c1-16-11-18(14-28-24(16)19-8-10-25-17(2)12-19)13-23(30)29-22-7-6-20(15-27-22)21-5-3-4-9-26-21/h3-12,14-15H,13H2,1-2H3,(H,27,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of PORCN in mouse Leydig cells overexpressing Wnt3A co-cultured with TM3 cells transfected with Wnt-luciferase gene after 24 hrs by lumine...				ACS Med Chem Lett 7: 676-80 (2016) Article DOI: 10.1021/acsmedchemlett.6b00038
					More data for this Ligand-Target Pair