BDBM375189 6-chloro-3-[(1S)-1-{[4-(1-methyl-1H-pyrazol-5-::US10253015, Compound I-49

SMILES: C[C@H](Nc1cc(ccn1)-c1ccnn1C)c1cc2cc(Cl)ccc2[nH]c1=O

InChI Key:

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 375189   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
IDH1 R132C (Homo sapiens (Human))	BDBM375189 (6-chloro-3-[(1S)-1-{[4-(1-methyl-1H-pyrazol-5- | U...) Show SMILES C[C@H](Nc1cc(ccn1)-c1ccnn1C)c1cc2cc(Cl)ccc2[nH]c1=O |r| Show InChI	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine					Assay Description Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...				Proc Natl Acad Sci U S A 97: 925-30 (2000) BindingDB Entry DOI: 10.7270/Q23F4S02
					More data for this Ligand-Target Pair
IDH1 R132H (Homo sapiens (Human))	BDBM375189 (6-chloro-3-[(1S)-1-{[4-(1-methyl-1H-pyrazol-5- | U...) Show SMILES C[C@H](Nc1cc(ccn1)-c1ccnn1C)c1cc2cc(Cl)ccc2[nH]c1=O |r| Show InChI	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine					Assay Description Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...				Proc Natl Acad Sci U S A 97: 925-30 (2000) BindingDB Entry DOI: 10.7270/Q23F4S02
					More data for this Ligand-Target Pair