BDBM375548 N-(1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)benzoyl)-4-methylpiperidin-4-yl)acetamide::US9908886, Example 99
SMILES: CC(=O)NC1(C)CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
InChI Key: InChIKey=MHWCJLGXJQQHCZ-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM375548 (N-(1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mississippi | Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro... | J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM375548 (N-(1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mississippi | Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro... | J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K | |||||||||||
More data for this Ligand-Target Pair |