BDBM376015 3-(1-methyl-1H-pyrazol-3-yl)- N-[3-(6-oxo-1,6- dihydropyridazin-3-yl)-1- phenyl-1H-pyrazol-5-yl]-4- (trifluoromethyl)benzamide::US9914736, Compound 11

SMILES: Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccc(=O)[nH]n1

InChI Key: InChIKey=SIZGMPWWIDDORY-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376015   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376015 (3-(1-methyl-1H-pyrazol-3-yl)- N-[3-(6-oxo-1,6- dih...) Show SMILES Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccc(=O)[nH]n1 Show InChI InChI=1S/C25H18F3N7O2/c1-34-12-11-19(32-34)17-13-15(7-8-18(17)25(26,27)28)24(37)29-22-14-21(20-9-10-23(36)31-30-20)33-35(22)16-5-3-2-4-6-16/h2-14H,1H3,(H,29,37)(H,31,36)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair