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BDBM376029 N-(isothiazol-5-ylmethyl)-5'- methyl-5-({[3-(1-methyl-1H- pyrazol-3-yl)-4- (trifluoromethyl)phenyl] carbonyl}amino)-2'H-1,3'- bipyrazole-3-carboxamide::US9914736, Compound 25

SMILES: Cc1cc([nH]n1)-n1nc(cc1NC(=O)c1ccc(c(c1)-c1ccn(C)n1)C(F)(F)F)C(=O)NCc1ccns1

InChI Key: InChIKey=ARNYSLYJTDMKAX-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376029   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM376029
PNG
(N-(isothiazol-5-ylmethyl)-5'- methyl-5-({[3-(1-met...)
Show SMILES Cc1cc([nH]n1)-n1nc(cc1NC(=O)c1ccc(c(c1)-c1ccn(C)n1)C(F)(F)F)C(=O)NCc1ccns1
Show InChI InChI=1S/C24H20F3N9O2S/c1-13-9-21(32-31-13)36-20(11-19(34-36)23(38)28-12-15-5-7-29-39-15)30-22(37)14-3-4-17(24(25,26)27)16(10-14)18-6-8-35(2)33-18/h3-11H,12H2,1-2H3,(H,28,38)(H,30,37)(H,31,32)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.70n/an/an/an/an/an/a



University of Namur



Assay Description
In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...


J Med Chem 51: 3077-80 (2008)


BindingDB Entry DOI: 10.7270/Q2WQ0629
More data for this
Ligand-Target Pair